Primary Hyperaldosteronism

Genetics of primary hyperaldosteronism.

Hypertension is a common medical condition and affects approximately 20% of the population in developed countries. Primary aldosteronism is the most common form of secondary hypertension and affects 8-13% of patients with hypertension. The two most common causes of primary aldosteronism are aldosterone-producing adenoma and bilateral adrenal hyperplasia. Familial hyperaldosteronism types I, II ...

Rhabdomyolysis due to primary hyperaldosteronism.

Rhabdomyolysis may be secondary to trauma, excessive muscle activity, hereditary muscle enzyme defects and other medical causes. Primary hyperaldosteronism is characterised by hypertension, hypokalemia, suppressed plasma renin activity, and increased aldosterone excretion. Rhabdomyolysis is not common in primary hyperaldosteronism. We report here a 42-year-old woman presenting with rhabdomyolys...

Renal calculi in primary hyperaldosteronism.

Increased urinary calcium (Ca++) excretion and the presence of negative Ca++ balance is well documented in primary hyperaldosteronism. However, renal calculi as a major manifestation of this disorder is not previously described. This report describes probably the first patient who presented with renal calculi in association with primary hyperaldosteronism. We believe that primary hyperaldostero...

[Primary hyperaldosteronism due to adrenal adenoma].

Clarification of hypertension – Diagnosis of primary hyperaldosteronism

Primary hyperaldosteronism (PH) is the most common cause of secondary hypertension. Apart from hypertension, hypokalaemia was hitherto considered to be the classical cardinal symptom. Its presence was therefore also usually a prerequisite for further diagnostic clarification in respect of PH. However, numerous new studies in normokalaemic hypertension patients now show that serum potassium leve...